Nathan Caine may not be able to feel pain, as the tagline for the new action-comedy “Novocaine” reads, but the same does not apply to audiences. Although he doesn’t scream when his leg is impaled

Quaid's leading role in Novocaine feels like a natural continuation of these genre-bent everymen. He plays Nathan Caine, a mild-mannered assistant bank manager who has congenital insensitivity to pain with anhidrosis (CIPA), a genetic disorder that impacts his nervous system to the point that he can't feel pain or temperature.