New research published in the journal Cell Reports sheds light on the role of the TP53 gene in preventing the spread of cancer. The TP53 gene codes tumor protein p53, a tumor suppressor that stops ...

Men who have mutations in a gene called TP53 have a high risk of developing aggressive prostate cancer, a multicenter research team in the United States has found. The findings were reported in the ...

The TP53 gene provides instructions for making a protein called tumor protein p53 (or p53). This protein regulates cell division by keeping cells from growing and dividing too fast or in an ...

Drugging the Master Regulator TP53 in Cancer: Mission Possible? The following represents disclosure information provided by the author of this manuscript. All relationships are considered compensated ...

Circulating tumor DNA may be an effective biomarker for stratifying patients with small cell lung cancer who would benefit from more stringent follow-ups and clinical trial participation.Patients who ...

Scientists from Merck Sharp & Dohme LLC and Otsuka Pharmaceutical Co. Ltd. have identified cellular tumor antigen p53 (TP53) Y220C mutant stabilizers reported to be useful for the treatment of cancer.

* One sperm donor was linked to nearly 200 births across multiple countries * Several children inherited a high-risk TP53 cancer mutation * Case exposes gaps in genetic screening //and donor ...

Higgins is an advocate for people with Li-Fraumeni syndrome. I was born with an inherited cancer syndrome, Li-Fraumeni syndrome (LFS). A mutation on my Tp53 cancer suppressor gene makes me susceptible ...