By decoding the rules that govern protein interactions, Diss and his team hope to develop predictive models to better understand how mutations contribute to disease. For example, he says, such ...

Australian skinks have pulled off an extraordinary evolutionary feat, developing genetic armor that blocks deadly snake venom from paralyzing them. Scientists discovered that tiny mutations in a key ...

In the case of a novel coronavirus, D614G mutation in the viral spike protein occurred at the initial stage of the pandemic, emerging in late January to early February 2020, and viruses containing ...

This work is published in Science, in the paper, “ Structural impact on SARS-CoV-2 spike protein by D614G substitution. ” In the original coronavirus, the spike proteins would bind to the ACE2 ...

The team validated their database’s predictions in the lab, making almost 3,000 mutations on over 1,000 proteins. They then tested their impact on almost 7,000 protein-protein interaction pairs.

A team of researchers recently demonstrated that mutations in the S protein of SARS-CoV-2 select for amino acid changes that result in a more stable protein than would otherwise be expected.

image: Computational modeling shows that mutations on SARS-CoV-2's spike protein that enhance the virus' ability to bind to the ACE2 receptor occur in two clusters or mutation "hotspots." view ...

From mutation to arrhythmia: Desmosomal protein breakdown as an underlying mechanism of cardiac disease Date: March 22, 2023 Source: Hubrecht Institute Summary: Mutations in genes that form the ...

Mutations in profilin-1 (PFN1) account for 1 to 2 percent of familial ALS cases (Jul 2012 news; Jun 2015 news). At just 140 amino acids in length, the protein contains only two interaction domains.