R2SP belongs to the R2TP-like quaternary chaperone family and consists of RUVBL1/RUVBL2 AAA+ ATPases, which powers the machinery, and SPAG1 and PIH1D2 adapter proteins that engage specific clients to ...
An advanced algorithm that has been developed by Google DeepMind has gone some way to cracking one of the biggest unsolved mysteries in biology. AlphaFold aims to predict the 3D structures of proteins ...
Ubiquitin-dependent protein degradation regulates myriad fundamental cellular processes. At its core are degradation signals, or degrons, that initiate substrate engagement and ubiquitination by E3 ...
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