The cellular thermal shift assay (CETSA) is a powerful tool for confirming target engagement and deconvoluting mode of action in living cells. The principle behind CETSA is that a ligand – target ...

Proteomics arrived on the biotech scene a decade ago, promising a new discovery route to disease markers. Much more complex than genomics, it represents the industrial-scale analysis of the vast array ...

Just like workers need the right environment to efficiently perform their tasks, proteins require placement within specific cellular compartments to function properly. Therefore, understanding the ...

Just how far mass spectrometry—the use of tools measuring the mass-to-charge ratio (m/z) of one or more molecules present in a sample—has progressed over the past century can be seen in a new exhibit ...