The ability to alter proteins to refine control over binding affinity and specificity can create tailored therapeutics with reduced side effects, highly sensitive diagnostic tools, efficient ...

Genetic interaction and protein-protein interaction networks have proved among the most important tools for inference of gene function and genotype-phenotype relationship. It remains unclear, however, ...

The rapid screening of protein binding affinity for poly- and perfluoroalkyl substances (PFAS) benefits risk assessment and fate and transport modelling. PFAS are known to bioaccumulate in livestock ...

A new artificial intelligence model developed by USC researchers and published in Nature Methods can predict how different proteins may bind to DNA with accuracy across different types of protein, a ...

A study has found that an ancient protein motif that binds to nucleic acids is functionally "ambidextrous." This means that the motif can interact with both natural and mirror-image nucleic acids, an ...

This article is based on a poster originally authored by Dillon Rinauro, Thomas Peplow, Phil Rawlins, Alec O'Keeffe, Corinne Tovey, Tayo Alleyne-Weir, James Craswell, Kartika Shetty, Michaela ...

Various approaches to such protein redesign have drawbacks. Traditional methods include time-consuming trial and error efforts, and many models in the emerging field ...