In Eukaryotes, the primary transcripts of nuclear genes are frequently interrupted by non-coding sequences (introns) which must be excised to generate a translatable mRNA. A dedicated organelle, the ...

Within multi-exon genes, after introns are removed, the exons must be spliced back together. Splice-enhancer domains (exon sequences near the intron–exon boundary) help to ensure that this happens ...

In the genome, genes that code for protein are often divided into sections called exons, which are separated by spacers called introns. When a region of DNA is transcribed into messenger RNA (mRNA) or ...

While working on a COVID-19-related project during the lockdown, Kärt Tomberg, PhD, found herself thinking about introns. She was part of a team working on the spike protein used in vaccines. Her task ...

Feasibility of consensus molecular subtype classification of colorectal cancer using preoperative biopsy specimens: A prospective pilot study.

What if you could flip a genetic switch to silence a gene, then turn it back on with a simple drug? For researchers, gene-switch tools offer that kind of control—and a new system called Cyclone may ...