Adult (40–60 days old, 140–160 g) male outbred rats (n = 54 total in all experiments) and adult (3–4 months old, 3–3.5 kg) male Chinchilla rabbits (n = 18 total in all experiments) were used in this ...
Nanomedicines improve drug bioavailability, the dose–response relationship, targeting ability, efficacy and safety compared to conventional freely administered drugs. Nonetheless, despite their ...
Simulation of the distribution of 1.5 L of isotonic saline infused over 30 min in (A) healthy awake sheep and (B) septic anesthetized sheep. No effects of adrenergic receptor stimulation are included.
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