Eukaryotic DNA replication relies on a highly orchestrated series of events centred on the Cdc45–MCM–GINS (CMG) helicase complex. Origin licensing begins in G1 phase with loading of a double hexamer ...

Scientists have discovered that a protein once thought to simply help load a factor necessary for the copying of DNA, actually plays a key role in ensuring fast and reliable replication—an insight ...

DNA replication and repair mechanisms constitute the foundation of genomic integrity, ensuring that genetic information is faithfully duplicated and maintained across cell generations. Replication ...

A protein that is involved in determining which enzymes cut or unwind DNA during the replication process has been identified. A protein that is involved in determining which enzymes cut or unwind DNA ...

The MCM helicase is broadly bound across the genome, and its phosphorylation is antagonistically regulated by the kinase DDK and the phosphatase RIF1–PP1. TRESLIN–MTBP recognises the phosphorylated ...

Researchers have gained a clearer insight into how common alterations to the structure of DNA affect the process of DNA replication. These structural changes can put a stop to replication, causing ...

Every person starts as just one fertilized egg. By adulthood, that single cell has turned into roughly 37 trillion cells, many of which keep dividing to create the same amount of fresh human cells ...

When cells proliferate, genomic DNA is precisely duplicated once per cell cycle. Abnormalities in this DNA replication process can cause alterations in genomic DNA, promoting cellular ageing, cancer, ...

Researchers have identified an alternate method to study changes during the DNA replication process in lab settings using genetically modified yeast. The new approach offers a clearer window than ...

For the first time, scientists have witnessed the very moment DNA begins to unravel, revealing a necessary molecular event ...

Helicases are enzymes that unwind DNA and RNA. They're central to cellular life, implicated in a number of cancers and infections - and, alas, extraordinarily difficult to target with drugs. Now, new ...