Cholesterol homeostasis is maintained by a balance between influx, synthesis, distribution and efflux of cholesterol within cells and across tissues. Low-density lipoprotein-bound cholesterol enters ...

Obesity increases the risk of metabolic syndromes, including diabetes mellitus and cardiovascular diseases, and one of the major drivers of this risk is chronic low-grade inflammation in visceral ...

Faulty lipid regulation in CLL patients impairs T-cell function, affecting treatment outcomes and resistance to current therapies. Differences in lipid metabolism between CLL patients and healthy ...

Researchers say newly identified cholesterol control pathway is completely separate from anything targeted by existing drugs.

This figure depicts the complex regulatory network that maintains cellular cholesterol homeostasis. Metabolic and hormonal signals, including oxysterols, IGF-1, and FGF19, activate kinase cascades ...

In a recent systematic review and meta-analysis published in eBioMedicine, researchers examined the association between biomarkers of cholesterol homeostasis and mortality in critically ill patients.

In a recent review published in the journal Experimental & Molecular Medicine, researchers reviewed available literature on the role and mechanisms (molecular and pathological) by which cholesterol ...

High cholesterol in females can increase their risk of developing heart disease. Cholesterol is a wax-like substance that the body naturally produces. It is required for several processes in the body, ...