Chemists and chemical biologists just keep dreaming up new ways to interfere with biomolecules. That research frequently leads to promising potential medicines, and there are more and more flavors of ...

Researchers have decoded the genetic blueprint of Penicillium citrinum, a common citrus mold, to uncover how nature produces cyclopentachromone -- a key building block for bioactive compounds with ...

The story of a cancer-fighting molecule that took half a century to build is really a story about how slow, stubborn chemistry can eventually bend to human ingenuity. Researchers spent decades ...

The ideal therapy for a disease works exclusively at the site of the disease. But when it comes to the brain, which is wrapped in a protective barrier and contains thousands of different cell types, ...

Drug discovery is like molecular Tetris. Chemists snap atoms together, adjusting the pieces until everything fits, and suddenly, a molecule makes a promising new medicine. Normally, creating better ...

In the high-stakes world of drug discovery, building a new medicine is a lot like microscopic architecture. To create the next breakthrough antibiotic or brain-targeting therapy, chemists must snap ...

Resulting atlas of the aging human brain holds molecular insights into the brain's vulnerability and resilience. Less than a decade ago, when Dr. Hansruedi Mathys launched an ambitious project to ...

Less than a decade ago, when Dr. Hansruedi Mathys launched an ambitious project to create an annotated library of all the gene readouts stored within 100 individual brain cells, the task felt daunting ...