Mast cell tryptases and chymases in inflammation and host …
WEBMast cells make two major types of peptidases with chymotrypsin-like activity, defined as a propensity for cleaving peptide and protein targets after aromatic amino acids, especially tyrosine and phenylalanine. These are the chymases and cathepsin G. Chymases are expressed fairly selectively by mast cells.
Novel Insight into the in vivo Function of Mast Cell Chymase: …
WEBJun 4, 2020 · Chymases, neutral serine proteases, are the major constituents of the mast cell granules and are hence released in large amounts upon mast cell activation.
Multifunctional Role of Chymase in Acute and Chronic Tissue …
WEBJan 19, 2018 · A connection between diabetes mellitus and mast cell chymase in the heart, kidney, and vasculature has been documented in humans and preclinical animal models. 179 AGEs (advanced glycation end-products) have been shown to induce chymase expression and a predominance of chymase-dependent Ang II generation (70%) over ACE-dependent generation in ...
Understanding human mast cells: lesson from therapies for
WEBOct 5, 2021 · In this Review, we discuss the existing and emerging therapies that target mast cells, and we consider how these treatments can help us to understand mast cell functions in disease.
Multifunctional Role of Chymase in Acute and Chronic Tissue …
WEBJan 1, 2018 · The ubiquitous nature and multiple functions of chymase explain why the literature is replete with the importance of mast cells and chymase in various human organ pathologies.
Novel Insight into the in vivo Function of Mast Cell Chymase ... - PubMed
WEBIn many cases, chymase has been shown to account for mast cell-dependent detrimental effects in the respective conditions and is therefore emerging as a promising drug target. On the other hand, chymase has been shown to …
Mast cell tryptases and chymases in inflammation and host …
WEBMay 7, 2007 · Secreted tryptases and chymases promote inflammation, matrix destruction, and tissue remodeling by several mechanisms, including destroying procoagulant, matrix, growth, and differentiation factors and activating proteinase-activated receptors, urokinase, metalloproteinases, and angiotensin.
Mast cell chymase: morphofunctional characteristics - PubMed
WEBIn this review, we discussed the current state of knowledge about mast cell chymase as one of the mast cell secretome proteases. Main issues of the reviewed publications are highlighted with our microscopic images of mast cell chymase visualized using immunohistochemical staining.
Mast cell chymase: morphofunctional characteristics
WEBAug 8, 2019 · In this review, we discussed the current state of knowledge about mast cell chymase as one of the mast cell secretome proteases. Main issues of the reviewed publications are highlighted with our microscopic images of mast cell chymase visualized using immunohistochemical staining.
Mast cell chymase modulates IL-33 levels and controls allergic
WEBDec 12, 2012 · The chymase, mouse mast cell protease 4, constitutes the major chymotrypsin-like activity in peritoneum and ear tissue. A role for mouse mast cell protease 4 in thrombin regulation and...